The series comprises letters to Jane Griffith (nee Wynne), 1789-1813, John Wynne Griffith the younger, 1804, Thomas Griffith, 1804-1815, George Griffith, 1813-1870, Frederick Griffith, 1824, William Henry Griffith, 1827-1828, 1835, Charlotte Maria Griffith, 1833-1836, William Douglas Wynne Griffith, 1861-1916, and John Douglas Wynne Griffith, 1942-1943. Recurrent subjects include the military career of Thomas Griffith and his death in India, condolences on the deaths of other family members, taxation, crown rents, public appointments and duties of individuals in addition to their regular careers.

The group comprises ecclesiastical papers, 1727, 1764, 1912, local government and political papers, [post-1719]-1926, militia papers, 1801-1813, 1871-1876 and papers concerning the Menai Bridge and Bangor to Holyhead road building scheme, 1820.