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The manuscript is in two parts. The first part comprises charms, directions on how to make circles, a copy of John Leland's Epigrams, problems, memoranda, Welsh verses, and a list of owners of Welsh manuscripts, apparently compiled by John Jones, Gellilvydy about 1611. The second part is a fifteenth-century treatise on palmistry, with diagrams.

The manuscript is in two parts. The first part is an exercise book containing Latin and Greek exercises by Robert Wynne of Maesyneuadd, Merioneth, some financial memoranda, 1667-1675, and an unfinished letter to Robert Wynne from his father, Maurice Wynne. The second part is a transcript by John Jones, Gellilyfdy of a printed copy of the Mundialis Sphere Opusculum of Johannes de Sacro Busto.

Exercise books in arithmetic and Latin, together with transcripts of arithmetic books, by John Jones, Gellilyfdy, 1597-1599. Also included are letters to Thomas Jones, 1581, and letters to John Jones from his father, William Jones, 1598.
The arithmetic and Latin books are composed of used paper from an attorney's office, some of it belonging to Thomas Jones, attorney, of Shrewsbury. There are six volumes in all. One booklet was transcribed by John Jones in 1654.

Fragments of manuscripts found with MS 540B, possibly once part of Peniarth MS 326 (see D. Huws, 'A Welsh manuscript of Bede's De natura rerum', Bulletin of the Board of Celtic Studies, XXVII, p. 492). They comprise a leaf from Gerard of Cremona's Latin translation of Aristotle, De Caelo et terra, XIII cent. (f. l); a leaf of the Middle English Dives and Pauper, XV cent. (see NLWJ, xxii, p. 347) (f. 2); a fragment of a petition in Chancery of [ ] of 'Kellilyfday' [Gellilyfdy] concerning a book borrowed in 1643 by Thomas Jones of Kirchynan [Flintshire] and not returned, the petitioner no doubt being John Jones, Gellilyfdy (f. 3); a flyleaf of a book with Latin tags, an englyn and the name Richard Mores, XVII cent. (f. 4); a bon mot of Dr John Wilkins, Bishop of Chester, XVIII cent. (f. 5); a theological treatise entitled Circa generaliores regulas moralis Christianae sententiae aliquot quibus passim se opponit Schola Theologica Louanensis, XVII cent. (ff. 6-11); and an inventory of the goods of Thomas Wilkins, papermaker, of the parish of West Drayton, Middlesex, 1729, including the stock of a paper-mill (f. 12).